STIMULATION IMMUNITY IN A MODEL OF SKIN LEISHMANIASIS

The process of cutaneous leishmaniasis is characterized by a sluggish long course due to local anti-infective immunity. Therefore, we tried to stimulate local immunity with the help of the official gramicidin paste. To assess the contribution of the
antibiotic action of gramicidin S in one of the control groups, monomycin ointment was used as the most effective anti-leishmania drug among antibiotics used to treat cutaneous leishmaniasis.
A significantly more effective therapeutic effect of gramicidin in the main group compared to monomycin indicates that the effect of gramicidin is determined not only by its antibiotic activity. There are sufficient grounds to suggest that gramicidin S has a local immunostimulatory effect, which, in combination with antibiotic action, gives a very good therapeutic effect in cutaneous leishmaniasis.